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"Praise for the First Edition " . . . the book is a valuable addition to the literature in the field, serving as a much-needed guide for both clinicians and advanced students."--Zentralblatt MATH A new edition of the cutting-edge guide to diagnostic tests in medical research In recent years, a considerable amount of research has focused on evolving methods for designing and analyzing diagnostic accuracy studies. Statistical Methods in Diagnostic Medicine, Second Edition continues to provide a comprehensive approach to the topic, guiding readers through the necessary practices for understanding these studies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy and study design, the authors successfully define various measures of diagnostic accuracy, describe strategies for designing diagnostic accuracy studies, and present key statistical methods for estimating and comparing test accuracy. Topics new to the Second Edition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values and sample sSample size calculation for multiple reader studies when pilot data are available Updated meta-analysis methods, now incorporating random effectsThree case studies thoroughly showcase some of the questions and statistical issues that arise in diagnostic medicine, with all associated data provided in detailed appendices. A related web site features Fortran, SAS(r), and R software packages so that readers can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is an excellent supplement for biostatistics courses at the graduate level. It also serves as a valuable reference for clinicians and researchers working in the fields of medicine, epidemiology, and biostatistics"--Provided by publisher.
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Pathology --- Diagnostic Techniques and Procedures --- Diagnosis, Laboratory --- Pathologie --- Diagnostics biologiques --- methods --- Periodicals. --- Périodiques --- Diagnostic Techniques and Procedures. --- Diagnostics --- Signes et symptômes --- Diagnosis, Laboratory. --- Pathology. --- methods. --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Diagnosis --- Sensitivity and Specificity --- Periodicals --- Health Sciences --- Life Sciences --- General and Others --- Morphology --- Diagnostic Testing --- Testing, Diagnostic
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Mathematical statistics --- Bayesian statistical decision theory --- Diagnosis --- Medicine --- Bayes Theorem --- Diagnostic Techniques and Procedures --- Data Interpretation, Statistical --- Mathematical models --- Research --- Statistical methods --- Diagnosis - Mathematical models --- Medicine - Research - Statistical methods
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Once the second edition was safely off to the printer, the 110 larger world of micro-CT and micro-MRI and the smaller world authors breathed a sigh of relief and relaxed, secure in the belief revealed by the scanning and transmission electron microscopes. that they would “never have to do that again. ” That lasted for 10 To round out the story we even have a chapter on what PowerPoint years. When we ?nally awoke, it seemed that a lot had happened. does to the results, and the annotated bibliography has been In particular, people were trying to use the Handbook as a text- updated and extended. book even though it lacked the practical chapters needed. There As with the previous editions, the editor enjoyed a tremendous had been tremendous progress in lasers and ?ber-optics and in our amount of good will and cooperation from the 124 authors understanding of the mechanisms underlying photobleaching and involved. Both I, and the light microscopy community in general, phototoxicity. It was time for a new book. I contacted “the usual owe them all a great debt of gratitude. On a more personal note, I suspects” and almost all agreed as long as the deadline was still a would like to thank Kathy Lyons and her associates at Springer for year away.
Biological microscopy --- Confocal microscopy. --- Microscopie confocale --- Confocal microscopy --- Microscopy --- Diagnostic Imaging --- Image Processing, Computer-Assisted --- Diagnostic Techniques and Procedures --- Computing Methodologies --- Investigative Techniques --- Imaging, Three-Dimensional --- Microscopy, Confocal --- Information Science --- Diagnosis --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemistry --- Biology --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Biology - General --- Biochemistry --- EPUB-LIV-FT LIVBIOLO LIVBIOMO LIVMEDEC SPRINGER-B --- Life sciences. --- Biotechnology. --- Biochemistry. --- Life Sciences. --- Biochemistry, general. --- Chemical engineering --- Genetic engineering --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Composition
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geofysica --- Geophysics --- geophysics --- Materials sciences --- Civil engineering. Building industry --- Structural engineering --- Structural control (Engineering) --- Structural health monitoring --- Automatic data collection systems --- Detectors --- Construction, Technique de la --- Contrôle des structures (Ingénierie) --- Collecte automatique des données --- Earth Sciences --- Engineering --- Information Technology --- Telecommunications Technology --- Engineering Geology --- Marine Geology and Oceanography --- Civil Engineering --- General and Others --- Artificial Intelligence --- Database Design & Management --- Wireless Communications --- Sensors --- Engineering instruments --- Physical instruments --- Data collection systems, Automatic --- Factory data acquisition systems, Automatic --- Factory monitoring systems, Automatic --- In-plant data collection systems, Automatic --- Automation --- Communication in management --- Data transmission systems --- Control of structures (Engineering) --- Structural dynamics --- Periodicals --- Engineering, Structural --- Structures, Engineering of --- Architecture --- Automatic data collection systems. --- Detectors. --- Structural engineering. --- Structural health monitoring. --- Condition monitoring (Structural engineering) --- Monitoring (Structural engineering) --- SHM (Structural health monitoring) --- Structural monitoring --- Nondestructive testing --- Structural analysis (Engineering) --- Diagnostic Techniques and Procedures --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Diagnosis --- Sensitivity and Specificity --- methods --- Diagnostic Techniques and Procedures. --- Diagnostic Testing --- Testing, Diagnostic --- Technique de la construction --- Surveillance de l'état des structures --- Diagnostics --- Méthodologie.
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QH - NATURAL HISTORY - BIOLOGY --- Genetics. --- Génétique --- Investigative Techniques --- Biology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biological Science Disciplines --- Natural Science Disciplines --- Disciplines and Occupations --- Genetics --- Genetic Techniques --- Health & Biological Sciences --- Genetica --- 577.21 --- 575.113 --- -Molecular genetics --- Molecular biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Genetic Processes --- Genetic Structures --- Genetic Phenomena --- Molecular mechanism of coding, storage and realization of inheritance information. Molecular genetics. Molecular biology of the gene --- Gene. Genetic apparatus. Genome --- Methodology --- 575.113 Gene. Genetic apparatus. Genome --- 577.21 Molecular mechanism of coding, storage and realization of inheritance information. Molecular genetics. Molecular biology of the gene --- Génétique --- Moleculaire biologie --- Diagnostic Techniques and Procedures.
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Diagnosis --- Symptoms --- Prognosis --- Diagnostics --- Signes et symptômes --- Pronostics (Pathologie) --- Periodicals --- Périodiques --- Function tests (Medicine) --- Evidence-based medicine --- Diagnostic Techniques and Procedures. --- Prognosis. --- Evidence-Based Medicine. --- Periodicals. --- Research --- Evaluation --- research methodology --- diagnosis --- prognosis --- Evidence-based medicine. --- Medicine, Evidence-Based --- Evidence Based Medicine --- Medicine, Evidence Based --- Decision Support Techniques --- Clinical Medicine --- Evidence-Based Dentistry --- Evidence-Based Nursing --- Prognostic Factors --- Factor, Prognostic --- Factors, Prognostic --- Prognoses --- Prognostic Factor --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Sensitivity and Specificity --- EBM (Medicine) --- Evidence-based healthcare --- Clinical medicine --- Systematic reviews (Medical research) --- Diagnosis, Noninvasive --- Physiology, Pathological --- Medical prognosis --- Prognosis of diseases --- Forecasting --- Diseases --- Examinations, Medical (Diagnosis) --- Medical diagnosis --- Medical examinations (Diagnosis) --- Medical tests (Diagnosis) --- methods --- Decision making --- Testing --- Diagnostic Testing --- Testing, Diagnostic --- Human medicine
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Medicine, Preventive --- Medicine --- Preventive Health Services. --- Preventive Medicine. --- Diagnostic Techniques and Procedures. --- Precision Medicine --- Medicine. --- Medicine, Preventive. --- Health. --- methods. --- Health --- Disease prevention --- Diseases --- Prevention of disease --- Preventive medicine --- Clinical sciences --- Medical profession --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Diagnosis --- Preventative Care --- Preventative Medicine --- Preventive Care --- Care, Preventative --- Care, Preventive --- Medicine, Preventative --- Disease --- Health Services, Preventive --- Preventive Health --- Preventive Health Care --- Preventive Health Programs --- Preventive Programs --- Services, Preventive Health --- Care, Preventive Health --- Health Care, Preventive --- Health Program, Preventive --- Health Programs, Preventive --- Health Service, Preventive --- Health, Preventive --- Preventive Health Program --- Preventive Health Service --- Preventive Program --- Program, Preventive --- Program, Preventive Health --- Programs, Preventive --- Programs, Preventive Health --- Service, Preventive Health --- Prevention --- methods --- prevention & control --- Pathology --- Preventive health services --- Preventive medicine physicians --- Public health --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Sensitivity and Specificity --- Preventive Health Services --- Primary Prevention --- Public Health --- Preventive Medicine --- Preventive Psychiatry --- Health Workforce --- Engineering --- Biomedical Engineering --- Diagnostic Testing --- Testing, Diagnostic
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Margaret Sullivan Pepe describes statistical concepts and techniques for evaluating medical diagnostic tests and biomarkers, which are chemicals added to the body for measuring the progress of disease or the effects of treatment. The statistical results can be used for detecting disease.
Mathematical statistics --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Medical statistics --- Diagnosis, Laboratory --- Health Care Evaluation Mechanisms --- Epidemiologic Methods --- Mathematics --- Diagnosis --- Methods --- Publication Formats --- Research --- Quality of Health Care --- Investigative Techniques --- Public Health --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Publication Characteristics --- Science --- Natural Science Disciplines --- Health Care Quality, Access, and Evaluation --- Disciplines and Occupations --- Environment and Public Health --- Health Care --- Statistics as Topic --- Statistics --- Diagnostic Techniques and Procedures --- Research Design --- Medicine --- Health & Biological Sciences --- Pathology --- Data Adjustment --- Data Reporting --- Design, Experimental --- Designs, Experimental --- Error Sources --- Experimental Designs --- Matched Groups --- Methodology, Research --- Problem Formulation --- Research Methodology --- Research Proposal --- Research Strategy --- Research Technics --- Research Techniques --- Scoring Methods --- Experimental Design --- Adjustment, Data --- Adjustments, Data --- Data Adjustments --- Design, Research --- Designs, Research --- Error Source --- Formulation, Problem --- Formulations, Problem --- Group, Matched --- Groups, Matched --- Matched Group --- Method, Scoring --- Methods, Scoring --- Problem Formulations --- Proposal, Research --- Proposals, Research --- Reporting, Data --- Research Designs --- Research Proposals --- Research Strategies --- Research Technic --- Research Technique --- Scoring Method --- Source, Error --- Sources, Error --- Strategies, Research --- Strategy, Research --- Technic, Research --- Technics, Research --- Technique, Research --- Techniques, Research --- Clinical Trials Data Monitoring Committees --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Sensitivity and Specificity --- Area Analysis --- Correlation Studies --- Correlation Study --- Correlation of Data --- Data Analysis --- Estimation Technics --- Estimation Techniques --- Indirect Estimation Technics --- Indirect Estimation Techniques --- Multiple Classification Analysis --- Service Statistics --- Statistical Study --- Statistics, Service --- Tables and Charts as Topic --- Analyses, Area --- Analyses, Data --- Analyses, Multiple Classification --- Analysis, Data --- Analysis, Multiple Classification --- Area Analyses --- Classification Analyses, Multiple --- Classification Analysis, Multiple --- Data Analyses --- Data Correlation --- Data Correlations --- Estimation Technic, Indirect --- Estimation Technics, Indirect --- Estimation Technique --- Estimation Technique, Indirect --- Estimation Techniques, Indirect --- Indirect Estimation Technic --- Indirect Estimation Technique --- Multiple Classification Analyses --- Statistical Studies --- Studies, Correlation --- Studies, Statistical --- Study, Correlation --- Study, Statistical --- Technic, Indirect Estimation --- Technics, Estimation --- Technics, Indirect Estimation --- Technique, Estimation --- Technique, Indirect Estimation --- Techniques, Estimation --- Techniques, Indirect Estimation --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Healthcare Quality, Access, and Evaluation --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Sciences --- Community Health --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Community --- Health, Public --- Preventive Medicine --- Education, Public Health Professional --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Pharmacy Audit --- Quality of Care --- Quality of Healthcare --- Audit, Pharmacy --- Care Qualities --- Care Quality --- Health Care Quality --- Healthcare Quality --- Pharmacy Audits --- Laboratory Research --- Research Activities --- Research and Development --- Research Priorities --- Activities, Research --- Activity, Research --- Development and Research --- Priorities, Research --- Priority, Research --- Research Activity --- Research Priority --- Research, Laboratory --- Ethics, Research --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Antemortem Diagnosis --- Diagnoses and Examinations --- Examinations and Diagnoses --- Postmortem Diagnosis --- Antemortem Diagnoses --- Diagnoses --- Diagnoses, Antemortem --- Diagnoses, Postmortem --- Diagnosis, Antemortem --- Diagnosis, Postmortem --- Postmortem Diagnoses --- Disease --- Mathematic --- Epidemiologic Method --- Epidemiological Methods --- Methods, Epidemiologic --- Epidemiological Method --- Method, Epidemiologic --- Method, Epidemiological --- Methods, Epidemiological --- Epidemiology --- Healthcare Evaluation Mechanisms --- Evaluation Mechanism, Healthcare --- Evaluation Mechanisms, Healthcare --- Healthcare Evaluation Mechanism --- Mechanism, Healthcare Evaluation --- Mechanisms, Healthcare Evaluation --- Clinical medicine --- Health --- Health statistics --- Statistical methods --- methods --- diagnosis --- statistics & numerical data --- Statistique médicale --- Research&delete& --- Biochemical markers --- Methodology --- Diagnostic Testing --- Testing, Diagnostic --- Diagnose --- Techniques --- Technique --- Diagnosis, Laboratory - Research - Statistical methods --- Diagnostic Techniques and Procedures - statistics & numerical data --- Research Design - statistics & numerical data --- Medical statistics. --- Statistical methods.
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